Physiologische Chemie Tiermedizin




Publications 2021

Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin.
Ruiz FM, Medrano FJ, Ludwig AK, Kaltner H, Shilova NV, Bovin NV, Gabius H-J, Romero A.
Biomolecules. 2021 Dec 9;11(12):1854.

Galectin network in osteoarthritis: galectin-4 programs a pathogenic signature of gene and effector expression in human chondrocytes in vitro.
Pichler KM, Fischer A, Alphonsus J, Chiari C, Schmidt S, Kenn M, Schreiner W, Weinmann D, Rothbauer M, Windhager R, Gabius H-J, Toegel S.
Histochem Cell Biol. 2021 Nov 30.

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen P, Wichapong K, Gabius H-J, Mayo KH.
Cell Mol Life Sci. 2021 Dec;78(24):8073-8095.

What is the Sugar Code?
Gabius H-J, Cudic M, Diercks T, Kaltner H, Kopitz J, Mayo KH, Murphy PV, Oscarson S, Roy R, Schedlbauer A, Toegel S, Romero A.
Chembiochem. 2021 Sep 8.

Simulating cellular galectin networks by mixing galectins in vitro reveals synergistic activity.
Dings RPM, Kumar N, Mikkelson S, Gabius H-J, Mayo KH.
Biochem Biophys Rep. 2021 Aug 28;28:101116.

Glycans in autophagy, endocytosis and lysosomal functions.
Reggiori F, Gabius H-J, Aureli M, Römer W, Sonnino S, Eskelinen EL.
Glycoconj J. 2021 Oct;38(5):625-647.

Imitating evolution's tinkering by protein engineering reveals extension of human galectin-7 activity.
Ludwig AK, Michalak M, Gabba A, Kutzner TJ, Beckwith DM, FitzGerald FG, García Caballero G, Manning JC, Kriegsmann M, Kaltner H, Murphy PV, Cudic M, Kopitz J, Gabius H-J.
Histochem Cell Biol. 2021 Sep;156(3):253-272.

Characterizing ligand-induced conformational changes in clinically relevant galectin-1 by HN/H2O (D2O) exchange.
Schedlbauer A, Gilles U, Ludwig AK, Adler A, Kaltner H, Lindner I, Mayo KH, Diercks T, Reusch D, Gabius H-J.
Biochimie. 2021 Aug;187:48-56.

What Cyto- and Histochemistry Can Do to Crack the Sugar Code.
Habermann FA, Kaltner H, Higuero AM, García Caballero G, Ludwig AK, C Manning J, Abad-Rodríguez J, Gabius H-J.
Acta Histochem Cytochem. 2021 Apr 28;54(2):31-48.

N-Glycan profiling of chondrocytes and fibroblast-like synoviocytes: Towards functional glycomics in osteoarthritis.
Fuehrer J, Pichler KM, Fischer A, Giurea A, Weinmann D, Altmann F, Windhager R, Gabius H-J, Toegel S.
Proteomics Clin Appl. 2021 May;15(2-3):e2000057.

Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin.
Beckwith DM, FitzGerald FG, Rodriguez Benavente MC, Mercer ER, Ludwig AK, Michalak M, Kaltner H, Kopitz J, Gabius H-J, Cudic M.
Biochemistry. 2021 Feb 23;60(7):547-558.

Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes.
Murphy PV, Romero A, Xiao Q, Ludwig AK, Jogula S, Shilova NV, Singh T, Gabba A, Javed B, Zhang D, Medrano FJ, Kaltner H, Kopitz J, Bovin NV, Wu AM, Klein ML, Percec V, Gabius H-J.
iScience. 2020 Dec 10;24(1):101919.

Human galectin‑3: Molecular switch of gene expression in dermal fibroblasts in vitro and of skin collagen organization in open wounds and tensile strength in incisions in vivo.
Gál P, Vasilenko T, Kováč I, Čoma M, Jakubčo J, Jakubčová M, Peržeľová V, Urban L, Kolář M, Sabol F, Luczy J, Novotný M, Majerník J, Gabius H-J, Smetana KJ.
Mol Med Rep. 2021 Feb;23(2):99.

From examining the relationship between (corona)viral adhesins and galectins to glyco-perspectives.
Klein ML, Romero A, Kaltner H, Percec V, Gabius H-J.
Biophys J. 2021 Mar 16;120(6):1031-1039.

The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes.
Pichler KM, Weinmann D, Schmidt S, Kubista B, Lass R, Martelanz L, Alphonsus J, Windhager R, Gabius H-J, Toegel S.
Calcif Tissue Int. 2021 Mar;108(3):377-390.

Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative.
Miller MC, Zheng Y, Suylen D, Ippel H, Cañada FJ, Berbís MA, Jiménez-Barbero J, Tai G, Gabius H-J, Mayo KH.
ChemMedChem. 2021 Feb 17;16(4):713-723.

Glycobiology of developing chicken kidney: Profiling the galectin family and selected β-galactosides.
Manning JC, García Caballero G, Ludwig AK, Kaltner H, Sinowatz F, Gabius H-J.
Anat Rec (Hoboken). 2021 Aug;304(8):1597-1628.

Galectin-Glycan Interactions: Guidelines for Monitoring by 77 Se NMR Spectroscopy, and Solvent (H2 O/D2 O) Impact on Binding.
Diercks T, Medrano FJ, FitzGerald FG, Beckwith D, Pedersen MJ, Reihill M, Ludwig AK, Romero A, Oscarson S, Cudic M, Gabius H-J.
Chemistry. 2021 Jan 4;27(1):316-325.