Publications 2004

Hippocampal neurons and recombinant galectins as tools for systematic carbohydrate structure-function studies in neuronal differentiation.
J. Kopitz, R. Russwurm, H. Kaltner, S. André, C. G. Dotti, H.-J. Gabius, J. Abad-Rodríguez
Brain. Res. 153, 189-196 (2004).

Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction.
U. C. Sharma, S. Pokharel, T. J. van Brakel, J. H. van Berlo, J. P. M. Cleutjens, B. Schroen, S. André, H. J. G. M. Crijns, H.-J. Gabius, J. Maessen, Y. M. Pinto
Circulation 110, 3121-3128 (2004).

Growth-regulatory human galectin-1: crystallographic characterization of structural changes induced by single-site mutations and their impact on thermodynamics of ligand binding increasing entropic penalty.
M. F. López-Lucendo, D. Solís, S. André, J. Hirabayashi, K-i. Kasai, H. Kaltner, H.-J. Gabius, A. Romero
J. Mol. Biol. 343, 957-970 (2004).

Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness.
S. Hancq, I. Salmon, J. Brotchi, H.-J. Gabius, C. W. Heizmann, R. Kiss, C. Decaestecker
Int. J. Oncol. 25, 1233-1243 (2004).

Galectin-3 - an emerging prognostic indicator in advanced head and neck carcinoma.
J. Plzák, J. Betka, K. Smetana Jr., M. Chovance, H. Kaltner, S. André, R. Kodet, H.-J. Gabius
Eur. J. Cancer 40, 2324-2330 (2004).

Human galectin-2: novel inducer of T-cell apoptosis with distinct profile of caspase activation.
A. Sturm, M. Lensch, S. André, H. Kaltner, B. Wiedenmann, S. Rosewicz, A. U. Dignass, H.-J. Gabius J. Immunol. 173, 3815-3837 (2004).

Decrease of nuclear reactivity to growth-regulatory galectin-1 in senescent human keratinocytes and detection of non-uniform staining profile alterations upon prolonged culture for galectins-1 and -3.
M. Chovance, K. Smetana Jr., B. Cvoránková, Z. Plzáková, S. André, H.-J. Gabius
Anat. Histol. Embryol. 33, 348-345 (2004).

Glycomic profiling of developmental changes in bovine testis by lectin histochemistry and further analysis of the most prominent alteration on the level of the glycoproteome by lectin blotting and lectin affinity chromatography.
J. C. Manning, K. Seyrek, H. Kaltner, S. André, F. Sinowatz, H.-J. Gabius
Histol. Histopathol. 19, 1043-1060 (2004).

Computational and experimental NMR definition of differences in the conformational behavior of free and lectin-bound glycomimetic aza/carba-lactosides.
M. C. Fernández-Alonso, F. J. Canada, D. Solís, X. Cheng, G. Kumaran, S. André, H.-C. Siebert, D. R. Mootoo, H.-J. Gabius, J. Jiménez-Barbero
Eur. J. Org. Chem. 1604-1613 (2004).

Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes.
N. Ahmad, H.-J. Gabius, S. André, H. Kaltner, S. Sabesan, R. Roy, B. Liu, F. Macaluso, C. F. Brewer
J. Biol. Chem. 279, 10841-10847 (2004).

Budesonide-dependent modulation of expression of macrophage migration inhibitory factor in a polyposis model: evidence for differential regulation insurface and glandular epithelia.
C. Delbrouck, H.-J. Gabius, G. Vandenhoven, R. Kiss, S. Hassid
Ann. Rhinol. Laryngol. 113, 544-51 (2004).

Prognostic stratification of Dukes B colon cancer by a neoglycoprotein.
H. Legendre, C. Decaestecker, M. G. Gbenou, N. Nagy, A. Hendlisz, S. André, J. C. Pector, R. Kiss, H.-J. Gabius
Int. J. Oncol. 25, 269-76 (2004).

Effects of polyvalency of glycotopes and natural modifications of human bloodgroup ABH/Lewis sugars at the Galb1-terminated core saccharides on the binding of domain-I of recombinant tandem-repeat-type galectin-4 from ratgastrointestinal tract (G4-N).
A. M. Wu, J. H. Wu, J. H. Liu, T. Singh, S. André, H. Kaltner, H.-J. Gabius
Biochimie 86, 317-26 (2004).

Chemical biology of the sugar code.
H.-J. Gabius, H.-C. Siebert, S. André, J. Jiménez-Barbero, H. Rüdiger
ChemBioChem 5, 740-64 (2004).

Thermodynamic binding studies of bivalent oligosaccharides to galectin-1, galectin-3, and the carbohydrate recognition domain of galectin-3.
N. Ahmad, H.-J. Gabius, S. Sabesan, S. Oscarson, C. F. Brewer
Glycobiology 14, 817-25 (2004).

Galectin-1 (L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.
B. Rotblat, H. Niv, S. André, H. Kaltner, H.-J. Gabius, Y. Kloog
Cancer Res. 64, 3112-8 (2004).

Tumor galectinology: Insights into the complex network of a family of endogenous lectins.
H. Lahm, S. André, A. Hoeflich, H. Kaltner, H.-C. Siebert, B. Sordat, C. W. von der Lieth, E. Wolf, Gabius H.-J.
Glycoconj. J. 20, 227-38 (2004).

Upregulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells.
B. Vray, I. Camby, V. Vercruysse, T. Mijatovic, N. V. Bovin, P. Ricciardi-Castagnoli, H. Kaltner, I. Salmon, H.-J. Gabius, R. Kiss
Glycobiology 14, 647-57 (2004).

S100AS: a marker of recurrence in WHO grade I meningiomas.
S. Hancq, I. Salmon, J. Brotchi, O. De Witte, H.-J. Gabius, C. W. Heinzmann, R. Kiss, C. Decaestecker
Neuropathol. Appl. Neurobiol. 30, 178-87 (2004).

Gene design, expression, crystallization and preliminary diffraction analysis of two isolectins from the fungus Coprinus cinereus: a model for studying functional diversification of galectins in the same organism and their evolutionary pathways.
M. F. Lopez-Lucendo, G. Gimenez-Gallego, D. N. Cooper, H.-J. Gabius, A. Romero
Acta Crystallogr. D Biol. Crystallogr. 60, 721-4 (2004).

Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands.
C. J. Arnusch, S. André, P. Valentini, M. Lensch, R. Russwurm, H.-C. Siebert, M. J. Fischer, H.-J. Gabius, R. J. Pieters
Bioorg. Med. Chem. Lett. 14, 1437-40 (2004).

The sugar code in drug delivery.
H.-J. Gabius
Adv Drug Deliv Rev. 56, 421-424 (2004).

Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets.
S. André, H. Kaltner, T. Furuike, S. Nishimura, H.-J. Gabius
Bioconjug. Chem. 15, 87-98 (2004).

Diagnostic relevance of Langerin detection in cells from bronchoalveolar lavage of patients with pulmonary Langerhans cell histiocytosis, sarcoidosis and idiopathic pulmonary fibrosis.
K. Smetana Jr, O. Mericka, S. Saeland, J. Homolka, J. Brabec, H.-J. Gabius
Virchows Arch. 444, 171-4 (2004).

Quaternary solution structures of galectins-1, -3, and -7.
S. Morris, N. Ahmad, S. André, H. Kaltner, H.-J. Gabius, M. Brenowitz, F. Brewer
Glycobiology 14, 293-300 (2004).

Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo.
S. André, C. Unverzagt, S. Kojima, M. Frank, J. Seifert, C. Fink, K. Kayser, C. W. von der Lieth, H.-J. Gabius
Eur. J. Biochem. 271, 118-34 (2004).

Solid phase measurements of antibody and lectin binding to xenogenic carbohydrate antigens.
S. Kirkeby, S. André, H.-J. Gabius
Clin. Biochem. 37, 36-41 (2004).