Physiologische Chemie Tiermedizin




Publications 2003

Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins.
H.C. Siebert, S. André, S. Y. Lu, M. Frank, H. Kaltner, J. A. van Kuik, E. Y. Korchagina, N. Bovin, E. Tajkhorshid, R. Kaptein, J. F. Vliegenthart, C. W. von der Lieth, J. Jimenez-Barbero, J. Kopitz, H.-J. Gabius
Biochemistry 42, 14762-14773 (2003).

First demonstration of differential inhibition of lectin binding by synthetic tri- and tetravalent glycoclusters from cross-coupling of rigidified 2-propynyl lactoside.
S. André, B. Liu, H.-J. Gabius, R. Roy
Org. Biomol. Chem. 1, 3909-3916 (2003).

New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites.
T. Purkrabkova, K. Smetana Jr, B. Dvorankova, Z. Holikova, C. Böck, M. Lensch, S. André, R. Pytlik, F. T. Liu, J. Klima, K. Smetana, J. Motlik, H.-J. Gabius
Biol. Cell. 95, 535-545 (2003).

Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas.
K. Kayser, D. Dünnwald, B. Kazmierczak, J. Bullerdiek, H. Kaltner, Y. Zick, S. André, H.-J. Gabius
Pathol. Res. Pract. 199, 589-598 (2003).

Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization.
K. Kayser, J. O. Nwoye, Z. Kosjerina, T. Goldmann, E. Vollmer, H. Kaltner, S. André, H.-J. Gabius
Lung Cancer 42, 171-182 (2003).

Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells.
J. Kopitz, S. André, C. von Reitzenstein, K. Versluis, H. Kaltner, R. J. Pieters, K. Wasano, I. Kuwabara, F. T. Liu, M. Cantz, A. J. Heck, H.-J. Gabius
Oncogene 22, 6277-6288 (2003).

Glycohistochemical characterization of vascular muscle cell destruction in CADASIL subjects by lectins, neoglycoconjugates and galectin-specific antibodies.
P. Brulin-Fardoux, C. Godfrain, C. A. Maurage, J. De Reuck, J. J. Hauw, H. Kaltner, N. V. Bovin, H.-J. Gabius, M. M. Ruchoux, R. Kiss, I. Camby
Neuropathol. Appl. Neurobiol. 29, 400-410 (2003).

Detection of ligand- and solvent-induced shape alterations of cell-growth-regulatory human lectin galectin-1 in solution by small angle neutron and x-ray scattering.
L. He, S. André, H.-C. Siebert, H. Helmholz, B. Niemeyer, H.-J. Gabius
Biophys. J. 85, 511-524 (2003).

Effect of hydrophilic components of the extracellular matrix on quantifiable diffusion-weighted imaging of human gliomas: preliminary results of correlating apparent diffusion coefficient values and hyaluronan expression level.
N. Sadeghi, I. Camby, S. Goldman, H.-J. Gabius, D. Baleriaux, I. Salmon, C. Decaesteckere, R. Kiss, T. Metens
AJR Am. J. Roentgenol. 181, 235-241 (2003).

Expression patterns of galectin-1 and galectin-3 in nasal polyps and middle and inferior turbinates in relation to growth regulation and immunosuppression.
C. Delbrouck, H.-J. Gabius, H. Kaltner, C. Decaestecker, R. Kiss, S. Hassid
Arch. Otolaryngol. Head Neck Surg. 129, 665-669 (2003).

Molecular Biological Fingerprinting of Human Lectin Expression by RT-PCR.
H. Lahm, S. André, A. Hoeflich, J. R. Fischer, B. Sordat, H. Kaltner, E. Wolf, H.-J. Gabius
Methods Enzymol. 362, 287-297 (2003).

Describing the Topology of the Bound Ligand by Transferred NOE Spectroscopy and Molecular Modeling.
H.-C. Siebert, J. Jiménez-Barbero, S. André, H. Kaltner, H.-J. Gabius
Methods Enzymol. 362, 417-443 (2003).

Gabius, R. Kiss, I. Camby. Upregulation of Galectins-1 and -3 in human colon cancer and their role in regulating cell migration.
A. Hittelet, H. Legendre, N. Nagy, Y. Bronckart, J.-C. Pector, I. Salmon, P. Yeaton, H.-J.
Int. J. Cancer 103, 370-379 (2003).

Characterization of the levels of expression of retinoic acid receptors (RARa, RARb, RARg), galectin-3, macrophage migration inhibitory factor (MIF) and p53 in a series of 51 adamantinomatous craniopharyngiomas.
F. Lefranc, C. Chevalier, M. Vinchon, P. Dhellemmes, M.-P. Schüring, H. Kaltner, J. Brotchi, M.-M. Ruchoux, H.-J. Gabius, I. Salmon, R. Kiss
J. Neurosurg. 98, 145-53 (2003).

Mannosides as crucial part of bioactive supports for cultivation of human epidermal keratinocytes without feeder cells.
J. Labsky, B. Dvoránková, K. Smetana Jr., Z. Holíková, L. Broz, H.-J. Gabius
Biomaterials 24, 863-872 (2003).

Refined prognostic evaluation in colon cancer by means of immunohistochemical galectin fingerprinting.
N. Nagy, H. Legendre, O. Nagels, S. André, H. Kaltner, K. Wasano, Y. Zick, J.-C. Pector, C. Decaestecker, H.-J. Gabius, I. Salmon, R. Kiss
Cancer 97, 1849-1858 (2003).

Analysis of selected blood and immune cell responses to carbohydrate-dependent surface binding of proto- and chimera-type galectins.
A. V. Timoshenko, I. V. Gorudko, O. V. Maslakova, S. André, I. Kuwabara, F.-T. Liu, H. Kaltner, H.-J. Gabius
Mol. Cell. Biochem. 250, 139-149 (2003).

Suitability of binary mixtures of water with aprotic solvents to turn hydroxyl protons of carbohydrate ligands into conformational sensors in NOE and transferred NOE experiments.
H.-C. Siebert, S. André, J. F. G. Vliegenthart, H.-J. Gabius, M. J. Minch
J. Biomol. NMR, 25, 197-215 (2003).

Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors.
I. Vrasidas, S. André, P. Valentini, C. Böck, M. Lensch, H. Kaltner, R. M. J. Liskamp, H.-J. Gabius, R. J. Pieters
Org. Biomol. Chem. 1, 803-810 (2003).

vCombined analysis of tumor growth pattern and expression of endogenous lectins as a prognostic tool in primary testicular cancer and its lung metastases.
K. Kayser, D. Hoeft, P. Hufnagl, J. Caselitz, Y. Zick, S. André, H. Kaltner, H.-J. Gabius
Histol. Histopathol. 18, 771-779 (2003).

Prognostic values of galectin-3 and the macrophage migration inhibitory factor (MIF) in human colorectal cancers.
H. Legendre, C. Decaestecker, N. Nagy, A. Hendlisz, M. P. Schüring, I. Salmon, H.-J. Gabius, J. C. Pector, R. Kiss
Mod. Pathol. 16, :491-504 (2003).

Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration.
A. Hittelet, H. Legendre, N. Nagy, Y. Bronckart, J. C. Pector, I. Salmon, P. Yeaton, H.-J. Gabius, R. Kiss, I. Camby
Int. J. Cancer 103, 370-379 (2003).

Galectin-3, an endogenous lectin, as a tool for monitoring cell differentiation in head and neck carcinomas with implications for lectin-glycan functionality.
J. Betka, J. Plzak, K. Smetana Jr, H.-J. Gabius
Acta Otolaryngol. 123, 261-263 (2003).