Publications 2000

Expression of Galectin-1 and -3 and of Accessible Binding Sites During Murine Hair Cycle.
U. Wollina, D. Lange, R. Paus, M. Burchert, H.-J. Gabius
Histol. Histopathol.15(1), 85-94 (2000).

Long-Term Administration of Galactoside-Specific Mistletoe Lectin in an Animal Model: No Protection against N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine-Induced Urinary Bladder Carcinogenesis in Rats and no Induction of a Relevant Local Cellular Immune Response.
E. Kunze, H. Schulz, M. Adamek, H.-J. Gabius
J. Cancer Res. Clin. Oncol.126, 125-138 (2000).

Characterization of Ligands for Galectins, Natural Galactoside-Binding Immunoglobulin G Subfractions and Sarcolectin and also of the Expression of Calcyclin in Thyroid Lesions.
N. Nagy, C. Decaestecker, X. Dong, H. Kaltner, M.-P. Schüring, A. Rocmans, A. Danguy, H.-J. Gabius, R. Kiss, I. Salmon
Histol. Histopathol.15, 503-513 (2000).

Glycohistochemical Characteristics of Nasal Polyps from Patients with and without Cystic Fibrosis.
S. Hassid, G. Choufani, C. Decaestecker, C. Delbrouck, S. Dawance, P. Pelc, N. Nagy, H. Kaltner, I. Salmon, A. Danguy, H.-J. Gabius, R. Kiss
Arch. Otolaryngol. Head Neck Surg.126, 776-779 (2000).

Medicinal Chemistry Based on the Sugar Code: Fundamentals of Lectinology and Experimental Strategies with Lectins as Targets.
H. Rüdiger, H.-C. Siebert, D. Solís, J. Jiménez-Barbero, A. Romero, C.-W. von der Lieth, T. Díaz-Mauri‚o, H.-J. Gabius
Curr. Med. Chem.7, 389-416 (2000).

Biological Information Transfer Beyond the Genetic Code: The Sugar Code. H.-
J. Gabius
Naturwissenschaften 87(3), 108-121 (2000).

Endogenous Lectins (Galectins-1 and -3) as Probes to Detect Differentiation-Dependent Alterations in Human Squamous Cell Carcinomas of Oropharynx and Larynx.
J. Plzák, K. Smetana Jr., J. Betka, R. Kodet, H. Kaltner, H.-J. Gabius
Int. J. Mol. Med. 5, 369-372 (2000).

Association of Concentration of Asbestos and Asbestos-like Fibres with the Patient's Survival and the Binding Capacity of Lung Parenchyma to Galectin-1 and Natural a-Galactoside and a-Mannoside-Binding Immunoglobulin G Subfraction from Human Serum.
K. Kayser, C. Seemann, S. André, C. Kugler, C. Becker, X. Dong, H. Kaltner, H.-J. Gabius
Path. Res. Pract.1296, 81-87 (2000).

Benign Metastasizing Leiomyoma of the Uterus: Documentation of Clinical, Immunohistochemical and Lectin-Histochemical Data for Ten Cases.
K. Kayser, S. Zink, T. Schneider, H. Dienemann, S. André, H. Kaltner, M.-P. Schüring, Y. Zick, H.-J. Gabius
Virchows Arch.437, 284-292 (2000).

NMR Investigations of Protein-Carbohydrate Interactions: Studies on the Relevance of Trp/Tyr Variations in Lectin Binding Sites as Deduced from Titration Microcalorimetry and NMR Structure of the Complex Between Pseudohevein and N, N', N''-Triacetylchitotriose.
J. L. Asensio, H.-C. Siebert, C.-W. von der Lieth, J. Laynez, M. Bruix, U. M. Soedjanaatmadja, J. J. Beintema, F. J. Canada, H.-J. Gabius, J. Jiménez-Barbero
PROTEINS 40, 218-236 (2000).

Temporal and Spatial Regulation of Expression of Two Galectins during Kidney Development of the Chicken.
B. Stierstorfer, H. Kaltner, C. Neumüller, F. Sinowatz, H.-J. Gabius
Histochem. J.32, 325-336 (2000).

Differential Binding Activities of Lectins and Neoglycoproteins in Human Testicular Tumors.
X.-C. Xu, U. Brinck, A. Schauer, H.-J. Gabius
Urol. Res.28, 62-68 (2000).

NMR Investigations of Protein-Carbohydrate Interactions. Binding Studies and Refined Three Dimensional Solution Structure of the Complex between the B Domain of Wheat Germ Agglutinin and N, N', N''-Triacetylchitotriose.
J. F. Espinosa, J. L. Asensio, J. L. García, J. Laynez, M. Bruix, C. Wright, H.- C. Siebert, H.-J. Gabius, F. J. Canada, J. Jiménez-Barbero
Eur. J. Biochem.267, 3965-3978 (2000).

Endogenous Lectins as Targets for Drug Delivery.
N. Yamazaki, S. Kojima, N. V. Bovin, S. André, S. Gabius, H.-J. Gabius
Adv. Drug Deliver. Rev.43, 225-244 (2000).

Structural Basis for Chitin Recognition by Defense Proteins: GlcNAc Residues are Bound in a Multivalent Fashion by Extended Binding Sites in Hevein Domains.
J. L. Asensio, F. J. Canada, H.-C. Siebert, J. Laynez, A. Poveda, P. M. Nieto, U. M. Soedjanaatmadja, J. J. Beintema, H.-J. Gabius, J. Jiménez-Barbero
Chem. Biol.7, 529-543 (2000).

An Enzyme-Linked Lectin Assay for a1,3-Galactosyltransferase.
L. S. Khraltsova, M. A. Sablina, T. D. Melikhova, D. H. Joziasse, H. Kaltner, H.-J. Gabius, N. V. Bovin
Anal. Biochem.280, 250-257 (2000).

Correlation of Galectin-3/Galectin-3-Binding Sites with Low Differentiation Status in Head and Neck Squamous Cell Carcinomas.
S. Delorge, S. Saussez, P. Pelc, B. Devroede, H. Marchant, M. Burchert, F.-Y. Zeng, A. Danguy, I. Salmon, H.-J. Gabius, R. Kiss, S. Hassid
Otolaryngol. Head Neck Surg.122, 834-841 (2000).

Gene Expression of Galectin-9/Ecalectin, a Potent Eosinophil Chemoattractant, and/or the Insertional Isoform in Human Colorectal Carcinoma Cell Lines and Detection of Frame-Shift Mutations for Protein Sequence Truncations in the Second Functional Lectin Domain.
H. Lahm, A. Höflich, S. André, B. Sordat, H. Kaltner, E. Wolf, H.-J. Gabius
Int. J. Oncol.17, 519-524 (2000).

The amino acid sequence of the abalone (Haliotis laevigata) nacre protein perlucin. Detection of a functional C-type lectin domain with galactose/mannose specificity.
K. Mann, I. M. Weiss, S. André, H.-J. Gabius, M. Fritz
Eur. J. Biochem.267, 5257-5264 (2000).

A New Combined Computational and NMR-Spectroscopical Strategy for the Identification of Additional Conformational Constraints of the Bound Ligand in an Aprotic Solvent.
H.-C. Siebert, S. André, J. L. Asensio, F. J. Canada, X. Dong, J. F. Espinosa, M. Frank, M. Gilleron, H. Kaltner, T. Kozár, N. V. Bovin, C.-W. von der Lieth, J. F. G. Vliegenthart, J. Jiménez-Barbero, H.-J. Gabius
CHEMBIOCHEM.1, 181-195 (2000).

On the Meaning of Affinity: Cluster Glycoside Effects and Concanavalin A.
H.-J. Gabius
CHEMTRACTS (Biochem. & Mol. Biol.). 13, 364-369 (2000).

Labeled Neoglycoproteins and Human Lectins as New Diagnostic and Potentially Functional Markers in Labial Salivary Glands of Patients with Sjögren's Syndrome.
S. Steinfeld, A. Penaloza, C. Decaestecker, S. Rommes, S. André, M.-P. Schüring, A. Danguy, T. Appelboom, R. Kiss, H.-J. Gabius
J. Rheumatol. 27, 1910-1906 (2000).

Integrated Nuclear Fluorescence and Expression of Hormone-Binding Sites in Malignant Pleural Effusions.
K. Kayser, C. Märkle, C. Kugler, S. André, M.-P. Schüring, F.-Y. Zeng, H.-J. Gabius
Anal. Quant. Cytol. Histol. 22, 364-372 (2000).

Lectin-Mediated Drug Targeting. Selection of Valency, Sugar Type (Gal/Lac) and Spacer Length for Cluster Glycosides as Parameters to Distinguish Ligand Binding to C-Type Asialoglycoprotein Receptors and Galectins.
S. André, B. Frisch, H. Kaltner, D. L. Desouza, F. Schuber, H.-J. Gabius
Pharmaceut. Res. 17, 985-990 (2000).

Calibration of Colorimetric Protein Assays for Quantitation of Plant AB Toxins.
M. Jiménez, S. André, H.-J. Gabius, D. Solís
Anal. Biochem. 284,.418-420 (2000).

Cell-Type Dependence of Stability Modulation of Lectin-Initiated Contacts by Impairment of Multivalent Carbohydrate Binding and Intracellular Signaling.
A. V. Timoshenko, I. V. Gorudko, S. André, H.-J. Gabius
Biosci. Rep. 20, 199-209 (2000).

Differences in Zero-Force and Force-Driven Kinetics of Ligand Dissociation from b-Galactoside-Specific Proteins (Plant and Animal Lectins, Immunoglobulin G) Monitored by Plasmon Resonance and Dynamic Single Molecule Force Microscopy.
W. Dettmann, M. Grandbois, S. André, M. Benoit, A. K. Wehle, H. Kaltner, H.-J. Gabius, H. E. Gaub
Arch. Biochem. Biophys. 383, 157-170 (2000).