Physiologische Chemie Tiermedizin




Publikationen 2020

Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes.
Murphy PV, Romero A, Xiao Q, Ludwig AK, Jogula S, Shilova NV, Singh T, Gabba A, Javed B, Zhang D, Medrano FJ, Kaltner H, Kopitz J, Bovin NV, Wu AM, Klein ML, Percec V, Gabius H-J.
iScience. 2020 Dec 10;24(1):101919.

Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by 19F NMR Spectroscopy.
Martínez JD, Manzano AI, Calviño E, Diego A, Rodriguez de Francisco B, Romanò C, Oscarson S, Millet O, Gabius H-J, Jiménez-Barbero J, Cañada FJ.
J Org Chem. 2020 Dec 18;85(24):16072-16081.

From examining the relationship between (corona)viral adhesins and galectins to glyco-perspectives.
Klein ML, Romero A, Kaltner H, Percec V, Gabius H-J.
Biophys J. 2021 Mar 16;120(6):1031-1039.

The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes.
Pichler KM, Weinmann D, Schmidt S, Kubista B, Lass R, Martelanz L, Alphonsus J, Windhager R, Gabius H-J, Toegel S.
Calcif Tissue Int. 2021 Mar;108(3):377-390.

Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative.
Miller MC, Zheng Y, Suylen D, Ippel H, Cañada FJ, Berbís MA, Jiménez-Barbero J, Tai G, Gabius H-J, Mayo KH.
ChemMedChem. 2021 Feb 17;16(4):713-723.

Glycobiology of developing chicken kidney: Profiling the galectin family and selected β-galactosides.
Manning JC, García Caballero G, Ludwig AK, Kaltner H, Sinowatz F, Gabius H-J.
Anat Rec (Hoboken). 2021 Aug;304(8):1597-1628.

Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides.
Miller MC, Cai C, Wichapong K, Bhaduri S, Pohl NLB, Linhardt RJ, Gabius H-J, Mayo KH.
Sci Rep. 2020 Sep 24;10(1):15708.

Galectin-Glycan Interactions: Guidelines for Monitoring by 77 Se NMR Spectroscopy, and Solvent (H2 O/D2 O) Impact on Binding.
Diercks T, Medrano FJ, FitzGerald FG, Beckwith D, Pedersen MJ, Reihill M, Ludwig AK, Romero A, Oscarson S, Cudic M, Gabius H-J.
Chemistry. 2021 Jan 4;27(1):316-325.

Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function.
Miller MC, Nesmelova IV, Daragan VA, Ippel H, Michalak M, Dregni A, Kaltner H, Kopitz J, Gabius H-J, Mayo KH.
Biochem J. 2020 Sep 18;477(17):3147-3165.

Influence of protein (human galectin-3) design on aspects of lectin activity.
García Caballero G, Beckwith D, Shilova NV, Gabba A, Kutzner TJ, Ludwig AK, Manning JC, Kaltner H, Sinowatz F, Cudic M, Bovin NV, Murphy PV, Gabius H-J.
Histochem Cell Biol. 2020 Aug;154(2):135-153.

TIM-3 and CEACAM1 do not interact in cis and in trans.
De Sousa Linhares A, Kellner F, Jutz S, Zlabinger GJ, Gabius H-J, Huppa JB, Leitner J, Steinberger P.
Eur J Immunol. 2020 Aug;50(8):1126-1141.

Chemokines and galectins form heterodimers to modulate inflammation.
Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchene J, Soehnlein O, Megens RT, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Döring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius H-J, von Hundelshausen P, Mayo KH.
EMBO Rep. 2020 Apr 3;21(4):e47852.

How galectins have become multifunctional proteins.
García Caballero G, Kaltner H, Kutzner TJ, Ludwig AK, Manning JC, Schmidt S, Sinowatz F, Gabius H-J.
Histol Histopathol. 2020 Jun;35(6):509-539.

Chicken lens development: complete signature of expression of galectins during embryogenesis and evidence for their complex formation with α-, β-, δ-, and τ-crystallins, N-CAM, and N-cadherin obtained by affinity chromatography.
García Caballero G, Schmidt S, Manning JC, Michalak M, Schlötzer-Schrehardt U, Ludwig AK, Kaltner H, Sinowatz F, Schnölzer M, Kopitz J, Gabius H-J.
Cell Tissue Res. 2020 Jan;379(1):13-35.

How presence of a signal peptide affects human galectins-1 and -4: Clues to explain common absence of a leader sequence among adhesion/growth-regulatory galectins.
Kutzner TJ, Higuero AM, Süßmair M, Kopitz J, Hingar M, Díez-Revuelta N, Caballero GG, Kaltner H, Lindner I, Abad-Rodríguez J, Reusch D, Gabius H-J.
Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129449.

The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis.
de Jong CGHM, Gabius H-J, Baron W.
Cell Mol Life Sci. 2020 Apr;77(7):1289-1317.