Physiologische Chemie Tiermedizin




Publikationen 2015

Fluorinated Carbohydrates as Lectin Ligands: (19)F-Based Direct STD Monitoring for Detection of Anomeric Selectivity.
Ribeiro JP, Diercks T, Jiménez-Barbero J, André S, Gabius HJ, Cañada FJ.
Biomolecules. 2015 Nov 13;5(4):3177-92.

Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context.
André S, Kaltner H, Kayser K, Murphy PV, Gabius HJ.
Histochem Cell Biol. 2015 Nov 9. [Epub ahead of print]

X-Ray Reflectivity and Grazing Incidence Diffraction Studies of Interaction between Human Adhesion/Growth-Regulatory Galectin-1 and DPPE-GM1 Lipid Monolayer at an Air/Water Interface.
Majewski J, André S, Jones E, Chi E, Gabius HJ.
Biochemistry (Mosc). 2015 Jul;80(7):943-56.

Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx.
Wu G, Lu ZH, André S, Gabius HJ, Ledeen RW.
J Neurochem. 2016 Feb;136(3):550-63.

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM.
Cell. 2015 Oct 22;163(3):746-58.

Glycodendrimersomes from Sequence-Defined Janus Glycodendrimers Reveal High Activity and Sensor Capacity for the Agglutination by Natural Variants of Human Lectins.
Zhang S, Xiao Q, Sherman SE, Muncan A, Ramos Vicente AD, Wang Z, Hammer DA, Williams D, Chen Y, Pochan DJ, Vértesy S, André S, Klein ML, Gabius HJ, Percec V.
J Am Chem Soc. 2015 Oct 21;137(41):13334-44.

Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing.
Peržeľová V, Sabol F, Vasilenko T, Novotný M, Kováč I, Slezák M, Ďurkáč J, Hollý M, Pilátová M, Szabo P, Varinská L, Čriepoková Z, Kučera T, Kaltner H, André S, Gabius HJ, Mučaji P, Smetana K Jr, Gál P.
Int J Mol Med. 2016 Jan;37(1):21-8.

Network Monitoring of Adhesion/Growth-Regulatory Galectins: Localization of the Five Canonical Chicken Proteins in Embryonic and Maturing Bone and Cartilage and Their Introduction as Histochemical Tools.
Kaltner H, Singh T, Manning JC, Raschta AS, André S, Sinowatz F, Gabius HJ.
Anat Rec (Hoboken). 2015 Dec;298(12):2051-70.

Regulatory Impact of Amniotic Membrane Transplantation on Presence of Adhesion/Growth-Regulatory Galectins-1 and -7 in Corneal Explants from Acanthamoeba Keratitis Patients: Clinical Note.
Smorodinova N, Kaltner H, Jirsová K, Hrdličková-Cela E, André S, Kučera T, Smetana K Jr, Gabius HJ.
Curr Eye Res. 2015 Sep 4:1-7.

Combining Crystallography and Hydrogen-Deuterium Exchange to Study Galectin-Ligand Complexes.
Ruiz FM, Gilles U, Lindner I, André S, Romero A, Reusch D, Gabius HJ.
Chemistry. 2015 Sep 21;21(39):13558-68.

Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.
Rodriguez MC, Yegorova S, Pitteloud JP, Chavaroche AE, André S, Ardá A, Minond D, Jiménez-Barbero J, Gabius HJ, Cudic M.
Biochemistry. 2015 Jul 28;54(29):4462-74.

Studies on Unprocessed and Acid-Treated Arabinogalactan from Larch as an Inhibitor of Glycan Binding of a Plant Toxin and Biomedically Relevant Human Lectins.
André S, Classen B, Gabius HJ.
Planta Med. 2015 Aug;81(12-13):1146-53.

The magic of the sugar code.
Gabius HJ.
Trends Biochem Sci. 2015 Jul;40(7):341.

The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function.
Gabius HJ, Kaltner H, Kopitz J, André S.
Trends Biochem Sci. 2015 Jul;40(7):360-76.

Unraveling functional significance of natural variations of a human galectin by glycodendrimersomes with programmable glycan surface.
Zhang S, Moussodia RO, Vértesy S, André S, Klein ML, Gabius HJ, Percec V.
Proc Natl Acad Sci U S A. 2015 May 5;112(18):5585-90.

Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence.
Vértesy S, Michalak M, Miller MC, Schnölzer M, André S, Kopitz J, Mayo KH, Gabius HJ.
Protein Eng Des Sel. 2015 Jul;28(7):199-210.

Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins.
André S, O'Sullivan S, Koller C, Murphy PV, Gabius HJ.
Org Biomol Chem. 2015 Apr 14;13(14):4190-203.

Comparative lectinology: Delineating glycan-specificity profiles of the chicken galectins using neoglycoconjugates in a cell assay.
Rapoport EM, Matveeva VK, Kaltner H, André S, Vokhmyanina OA, Pazynina GV, Severov VV, Ryzhov IM, Korchagina EY, Belyanchikov IM, Gabius HJ, Bovin NV.
Glycobiology. 2015 Jul;25(7):726-34.

Preliminary X-ray crystallographic analysis of an engineered variant of human chimera-type galectin-3 with a shortened N-terminal domain.
Flores-Ibarra A, Ruiz FM, Vértesy S, André S, Gabius HJ, Romero A.
Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):184-8. doi: 10.1107/S2053230X15000023. Epub 2015 Jan 28.

Dissecting molecular aspects of cell interactions using glycodendrimersomes with programmable glycan presentation and engineered human lectins.
Zhang S, Moussodia RO, Murzeau C, Sun HJ, Klein ML, Vértesy S, André S, Roy R, Gabius HJ, Percec V.
Angew Chem Int Ed Engl. 2015 Mar 23;54(13):4036-40.

Lectins: getting familiar with translators of the sugar code.
André S, Kaltner H, Manning JC, Murphy PV, Gabius HJ.
Molecules. 2015 Jan 22;20(2):1788-823.

Thio- and selenoglycosides as ligands for biomedically relevant lectins: valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides.
André S, Kövér KE, Gabius HJ, Szilágyi L.
Bioorg Med Chem Lett. 2015 Feb 15;25(4):931-5.

Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: synthesis, activity screening, and HSQC-based NMR analysis.
Rauthu SR, Shiao TC, André S, Miller MC, Madej É, Mayo KH, Gabius HJ, Roy R.
Chembiochem. 2015 Jan 2;16(1):126-39.

Emerging role of tissue lectins as microenvironmental effectors in tumors and wounds.
Smetana K Jr, Szabo P, Gal P, André S, Gabius HJ, Kodet O, Dvořánková B.
Histol Histopathol. 2015 Mar;30(3):293-309.

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code.
Solís D, Bovin NV, Davis AP, Jiménez-Barbero J, Romero A, Roy R, Smetana K Jr, Gabius HJ.
Biochim Biophys Acta. 2015 Jan;1850(1):186-235.

(1)H, (13)C, and (15)N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3.
Ippel H, Miller MC, Berbís MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius HJ, Jiménez-Barbero J, Mayo KH.
Biomol NMR Assign. 2015 Apr;9(1):59-63.