Physiologische Chemie Tiermedizin




Publikationen 2009

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.
Barrès C, Blanc L, Bette-Bobillo P, André S, Mamoun R, Gabius HJ, Vidal M.
Blood. 2010 Jan 21;115(3):696-705. Epub 2009 Nov 10

Diffusion nuclear magnetic resonance spectroscopy detects substoichiometric concentrations of small molecules in protein samples.
Ribeiro JP, Palczewska M, André S, Cañada FJ, Gabius HJ, Jiménez-Barbero J, Mellström B, Naranjo JR, Scheffers DJ, Groves P.
Anal Biochem. 2010 Jan 1;396(1):117-23. Epub 2009 Sep 4

Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins.
Leyden R, Velasco-Torrijos T, André S, Gouin S, Gabius HJ, Murphy PV.
J Org Chem. 2009 Dec 4;74(23):9010-26

Galectin-8 up-regulation during hypopharyngeal and laryngeal tumor progression and comparison with galectin-1, -3 and -7.
Cludts S, Decaestecker C, Mahillon V, Chevalier D, Kaltner H, André S, Remmelink M, Leroy X, Gabius HJ, Saussez S.
Anticancer Res. 2009 Dec;29(12):4933-40

Conformational analysis of thioglycoside derivatives of histo-blood group ABH antigens using an ab initio-derived reparameterization of MM4: implications for design of non-hydrolysable mimetics.
Strino F, Lii JH, Gabius HJ, Nyholm PG.
J Comput Aided Mol Des. 2009 Dec;23(12):845-52. Epub 2009 Sep 15

Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles.
André S, Velasco-Torrijos T, Leyden R, Gouin S, Tosin M, Murphy PV, Gabius HJ.
Org Biomol Chem. 2009 Nov 21;7(22):4715-25. Epub 2009 Sep 23

Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by the human lectin galectin-1.
Alge-Priglinger CS, André S, Kreutzer TC, Deeg CA, Kampik A, Kernt M, Schöffl H, Priglinger SG, Gabius HJ.
Mol Vis. 2009 Oct 23;15:2162-73

Alpha-O-linked glycopeptide mimetics: synthesis, conformation analysis, and interactions with viscumin, a galactoside-binding model lectin.
Jiménez-Barbero J, Dragoni E, Venturi C, Nannucci F, Ardá A, Fontanella M, André S, Cañada FJ, Gabius HJ, Nativi C.
Chemistry. 2009 Oct 12;15(40):10423-31

Carbamate-linked lactose: design of clusters and evidence for selectivity to block binding of human lectins to (neo)glycoproteins with increasing degree of branching and to tumor cells.
André S, Specker D, Bovin NV, Lensch M, Kaltner H, Gabius HJ, Wittmann V.
Bioconjug Chem. 2009 Sep;20(9):1716-28

The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage.
Ulmer TA, Keeler V, André S, Gabius HJ, Loh L, Laferté S.
Biochim Biophys Acta. 2009 Aug 7

Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?
Frol'ová L, Smetana K Jr, Borovská D, Kitanovicová A, Klimesová K, Janatková I, Malícková K, Lukás M, Drastich P, Benes Z, Tucková L, Manning JC, André S, Gabius HJ, Tlaskalová-Hogenová H.
Inflamm Res. 2009 Aug;58(8):503-12. Epub 2009 Mar 7

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking.
Morelle W, Stechly L, André S, Van Seuningen I, Porchet N, Gabius HJ, Michalski JC, Huet G.
Biol Chem. 2009 Jul;390(7):529-44

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans.
André S, Kozár T, Kojima S, Unverzagt C, Gabius HJ.
Biol Chem. 2009 Jul;390(7):557-65. Review

Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.
Patsos G, André S, Roeckel N, Gromes R, Gebert J, Kopitz J, Gabius HJ.
Glycobiology. 2009 Jul;19(7):726-34. Epub 2009 Mar 17

Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts.
Kideryová L, Lacina L, Dvoránková B, Stork J, Cada Z, Szabo P, André S, Kaltner H, Gabius HJ, Smetana K Jr.
J Dermatol Sci. 2009 Jul;55(1):18-26. Epub 2009 May 2

Multivalent binding of carbohydrates by the human alpha-defensin, HD5.
Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W.
J Immunol. 2009 Jul 1;183(1):480-90

Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.
Diercks T, Ribeiro JP, Cañada FJ, André S, Jiménez-Barbero J, Gabius HJ.
Chemistry. 2009 Jun 2;15(23):5666-8

Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins.
Kaltner H, Solís D, André S, Lensch M, Manning JC, Mürnseer M, Sáiz JL, Gabius HJ.
Biochemistry. 2009 May 26;48(20):4403-16

Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation.
Massardo L, Metz C, Pardo E, Mezzano V, Babul M, Jarpa E, Guzmán AM, André S, Kaltner H, Gabius HJ, Jacobelli S, González A, Soza A.
Lupus. 2009 May;18(6):539-46

Glycan tagging to produce bioactive ligands for a surface plasmon resonance study via immobilization on different surfaces.
Muñoz FJ, Pérez J, Rumbero A, Santos JI, Cañada FJ, André S, Gabius HJ, Jiménez-Barbero J, Sinisterra JV, Hernáiz MJ.
Bioconjug Chem. 2009 Apr;20(4):673-82

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.
Roda O, Ortiz-Zapater E, Martínez-Bosch N, Gutiérrez-Gallego R, Vila-Perelló M, Ampurdanés C, Gabius HJ, André S, Andreu D, Real FX, Navarro P.
Gastroenterology. 2009 Apr;136(4):1379-90, e1-5. Epub 2008 Dec 13

Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis.
Wang J, Lu ZH, Gabius HJ, Rohowsky-Kochan C, Ledeen RW, Wu G.
J Immunol. 2009 Apr 1;182(7):4036-45

Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.
Stechly L, Morelle W, Dessein AF, André S, Grard G, Trinel D, Dejonghe MJ, Leteurtre E, Drobecq H, Trugnan G, Gabius HJ, Huet G.
Traffic. 2009 Apr;10(4):438-50. Epub 2009 Jan 24.

Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and peptide mass fingerprinting.
López-Lucendo MF, Solís D, Sáiz JL, Kaltner H, Russwurm R, André S, Gabius HJ, Romero A.
J Mol Biol. 2009 Feb 20;386(2):366-78. Epub 2008 Sep 30

N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
Liu YH, D'Ambrosio M, Liao TD, Peng H, Rhaleb NE, Sharma U, André S, Gabius HJ, Carretero OA.
Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H404-12. Epub 2008 Dec 19

Phosphorylated human lectin galectin-3: analysis of ligand binding by histochemical monitoring of normal/malignant squamous epithelia and by isothermal titration calorimetry.
Szabo P, Dam TK, Smetana K Jr, Dvoránková B, Kübler D, Brewer CF, Gabius HJ.
Anat Histol Embryol. 2009 Feb;38(1):68-75. Epub 2008 Oct 18

Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7.
Saussez S, Cludts S, Capouillez A, Mortuaire G, Smetana K Jr, Kaltner H, André S, Leroy X, Gabius HJ, Decaestecker C.
Int J Oncol. 2009 Feb;34(2):433-9

Detection and chromatographic removal of lipopolysaccharide in preparations of multifunctional galectins.
Sarter K, André S, Kaltner H, Lensch M, Schulze C, Urbonaviciute V, Schett G, Herrmann M, Gabius HJ.
Biochem Biophys Res Commun. 2009 Jan 30;379(1):155-9. Epub 2008 Dec 25

Adhesion/growth-regulatory tissue lectin galectin-1 in relation to angiogenesis/lymphocyte infiltration and prognostic relevance of stromal up-regulation in laryngeal carcinomas.
Saussez S, Decaestecker C, Cludts S, Ernoux P, Chevalier D, Smetana K Jr, André S, Leroy X, Gabius HJ.
Anticancer Res. 2009 Jan;29(1):59-65

Synthesis and conformational analysis of (alpha-D-galactosyl)phenylmethane and alpha-,beta-difluoromethane analogues: interactions with the plant lectin viscumin.
Kolympadi M, Fontanella M, Venturi C, André S, Gabius HJ, Jiménez-Barbero J, Vogel P.
Chemistry. 2009;15(12):2861-73

Immunohistochemical fingerprinting of the network of seven adhesion/growth-regulatory lectins in human skin and detection of distinct tumour-associated alterations.
Cada Z, Smetana K Jr, Lacina L, Plzáková Z, Stork J, Kaltner H, Russwurm R, Lensch M, André S, Gabius HJ.
Folia Biol (Praha). 2009;55(4):145-52

Small angle neutron scattering as sensitive tool to detect ligand-dependent shape changes in a plant lectin with beta-trefoil folding and their dependence on the nature of the solvent.
He L, André S, Garamus VM, Siebert HC, Chi C, Niemeyer B, Gabius HJ.
Glycoconj J. 2009 Jan;26(1):111-6. Epub 2008 Jul 11

Galectin-7: will the lectin's activity establish clinical correlations in head and neck squamous cell and basal cell carcinomas?
Cada Z, Chovanec M, Smetana K, Betka J, Lacina L, Plzák J, Kodet R, Stork J, Lensch M, Kaltner H, André S, Gabius HJ.
Histol Histopathol. 2009 Jan;24(1):41-8

Differential regulation of galectin expression/reactivity during wound healing in porcine skin and in cultures of epidermal cells with functional impact on migration.
Klíma J, Lacina L, Dvoránková B, Herrmann D, Carnwath JW, Niemann H, Kaltner H, André S, Motlík J, Gabius HJ, Smetana K Jr.
Physiol Res. 2009;58(6):873-84. Epub 2008 Dec 17