Physiologische Chemie Tiermedizin
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Publikationen 2001

Plant lectins.
H. Rüdiger, H.-J. Gabius
Glycoconjugate J. 18, 589-613 (2001).

Evidence for Stimulation of Tumor Proliferation in Cell Lines and Histotypic Cultures by Clinically Relevant Low Doses of the Galactoside-Binding Mistletoe Lectin, a Component of H.-J. Gabius, F. Darro, M. Remmelink, S. André, J. Kopitz, A. Danguy, S.
Gabius, I. Salmon, R. Kiss Proprietary Extracts.
Cancer Investig. 19, 114-126 (2001).

Endobronchial Juvenile Hemangioma - a Case Report of a Neonate Including Immunohistochemical Monitoring and Nuclear, Cellular and Vascular Morphometry.
K. Kayser, S. Zink, B. Link, F. Herth, H. Dienemann, L. Schrod, H.-J. Gabius
Virchows Archiv. 438, 192-197 (2001).

Towards Defining the Role of Glycans as Hardware in Information Storage and Transfer: Basic Principles, Experimental Approaches and Recent Progress.
D. Solís, J. Jiménez-Barbero, H. Kaltner, A. Romero, H.-C. Siebert, C.-W. von der Lieth, H.-J. Gabius
Cells Tissues Organs., 168, 5-23 (2001).

Inhibitory Effects of Carrier-Immobilized Synthetic Histo-Blood Group A-, B-, H-, and SiaLe-Oligosaccharides on H2O2 Generation by Human Polymorphonuclear Leukocytes.
A. V. Timoshenko, S. Y. Vakhrushev, N. V. Bovin, H.-J. Gabius
Carbohydr. Polym., 44, 351-355 (2001).

Comprehensive Galectin Fingerprinting in a Panel of 61 Human Tumor Cell Lines by RT-PCR and Its Implications for Diagnostic and Therapeutic Procedures.
H. Lahm, S. André, A. Höflich, J. R. Fischer, B. Sordat, H. Kaltner, E. Wolf, H.-J. Gabius
J. Cancer Res. Clin. Oncol., 127, 375-386 (2001).

Glyco- and Immunohistochemical Refinement of the Differential Diagnosis between Mesothelioma and Metastatic Carcinoma and Survival Analysis of Patients.
K. Kayser, G. Böhm, S. Blum, M. Beyer, S. Zink, S. André, H.-J. Gabius
J. Pathol. 193, 175-180 (2001).

Evidence for Stimulation of Tumor Proliferation in Cell Lines and Histotypic Cultures by Clinically Relvant Low Doses of the Galactoside-Binding Mistletoe Lectin, a Component of Proprietary Extracts.
H.-J. Gabius, F. Darro, M. Remmelink, S. André, J. Kopitz, A. Danguy, S. Gabius, I. Salmon, R. Kiss
Cancer Invest. 19, 114-126 (2001).

Galectins are Differentially Expressed in Supratentorial Pilocytic Astrocytomas, Astrocytomas, Anaplastic Astrocytomas and Glioblastomas, and Significantly Modulate Tumor Astrocyte Migration.
I. Camby, N. Belot, S. Rorive, F. Lefranc, C.-A. Maurage, H. Lahm, H. Kaltner, Y. R. Hadari, M.-M. Ruchoux, J. Brotchi, Y. Zick, I. Salmon, H.-J. Gabius, R. Kiss
Brain Pathol. 11, 12-26 (2001).

Glycohistochemistry: the How and Why of Detection and Localization of Endogenous Lectins.
H.-J. Gabius
Anat. Histol. Embryol. 30, 3-31 (2001).

Distinct Differences in Binding Capacity to Saccharide Epitopes in Supratentorial Pilocytic Astrocytomas, Astrocytomas, Anaplastic Astrocytomas and Glioblastomas.
I. Camby, C. Decaestecker, L. Gordower, R. DeDecker, Y. Kacem, A. Lemmers, H.-C. Siebert, N. V. Bovin, P. Wesseling, I. Salmon, H.-J. Gabius, R. Kiss
J. Neuropathol. Exp. Neurol. 60, 75-84 (2001).

Galectin-1 is Highly Expressed in Human Gliomas with Relevance for Modulation of Invasion of Tumor Astrocytes into the Brain Parenchyma.
S. Rorive, N. Belot, M.-M. Ruchoux, A. Danguy, H.-J. Gabius, I. Salmon, R. Kiss, I. Camby
GLIA 33, 241-255 (2001).

The Levels of Expression of Galectin-3, but not of Galectin-1 and -8, Correlate with Apoptosis in Human Cholesteatomas.
R. Sheikholeslam-Zadeh, C. Decaestecker, C. Delbrouck, A. Danguy, I. Salmon, Y. Zick, H. Kaltner, S. Hassid, H.-J. Gabius, R. Kiss, G. Choufani
Laryngoscope 111, 1042-1047 (2001).

Expression of Galectin-3-Reactive Ligands in Squamous Cancer and Normal Epithelial Cells as a Marker of Differentiation.
J. Plzák, K. Smetana Jr., E. Hrdlikova, R. Kodet, Z. Holiková, F.-T. Liu, B. Dvoránková, H. Kaltner, J. Betka, H.-J. Gabius
Int. J. Oncol. 19, 59-64 (2001).

The Levels of Retinoid RXRb Receptors Correlate with Galectin-1, -3 and -8 Expression in Human Cholesteatomas.
P. Simon, C. Decaestecker, G. Choufani, C. Delbrouck, A. Danguy, I. Salmon, Y. Zick, H. Kaltner, S. Hassid, H.-J. Gabius, R. Kiss, F. Darro
Hearing Res. 156, 1-9 (2001).

Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to sLex and PSGL-1.
H.-J. Gabius
CHEMTRACTS (Biochem. & Mol. Biol.) 14, 315-319 (2001).

Expression of Endogenous Lectins (Galectins, Receptors for ABH-Epitopes) and the MIB-1 Antigen in Esophageal Carcinomas and their Syntactic Structure Analysis in Relation to Post-Surgical Tumor Stage and Lymph Node Involvement.
K. Kayser, E. Hauck, S. André, N. V. Bovin, H. Kaltner, L. Banach, H.-J. Gabius
Anticancer Res. 21, 1439-1444 (2001).

Immunohistochemical Profile of Galectin-8 Expression in Benign and Malignant Tumors of Epithelial, Mesenchymatous and Adipous Origins, and of the Nervous System.
A. Danguy, S. Rorive, C. Decaestecker, Y. Bronckart, H. Kaltner, Y. R. Hadari, R. Goren, Y. Zick, M. Pétein, I. Salmon, H.-J. Gabius, R. Kiss
Histol. Histopathol. 16, 861-868 (2001).

Survival, Disease-Free Interval, and Associated Tumor Features in Patients with Colon/Rectal Carcinomas and Their Resected Intra-Pulmonary Metastases.
S. Zick, G. Kayser, H.-J. Gabius, K. Kayser
Eur. J. Cardio-Thor. Surg. 19,908-913 (2001).

Preparation and Characterization of Neoglycoprotein-Liposome Conjugates: a Promising Approach to Developing Drug Delivery Materials Applying Sugar Chain Ligands.
N. Yamazaki, Y. Jigami, H.-J. Gabius, S. Kojima
Trends Glycosci. Glycotechnol. 13, 319-329 (2001).

Immunotherapy of C3H/HeJ Mammary Adenocarcinoma with Interleukin-2, Mistletoe Lectin or Their Combination: Effects on Tumor Growth, Capillary Leakage and NO Production.
A. V. Timoshenko, Y. Lan, H.-J. Gabius, P. K. Lala
Eur. J. Cancer 37, 1910-1920 (2001).

Wedge-like Glycodendrimers as Inhibitors of Binding of Mammalian Galectins to Various Glycoproteins, Lactose Maxiclusters and Tumor or Blood Cell Surface Glycoconjugates.
S. André, R. J. Pieters, I. Vrasidas, H. Kaltner, I. Kuwabara, F.-T. Liu, R. M. J. Liskamp, H.-J. Gabius
CHEMBIOCHEM 2, 822-830 (2001).

Lectinochemical Studies on the Combining Sites of the Galb1-Specific Galectin from Chicken Liver (CG-16).
A. M. Wu, J. H. Wu, M.-S. Tsai, H. Kaltner, H.-J. Gabius
Biochem. J. 358, 529-538 (2001).

Detection of Galectin-3 in Tear Fluid at Disease States and Immuno- and Lectin Histochemical Analysis for this Galectin in Human Corneal and Conjunctival Epithelium.
E. Hrdliková-Cela, J. Plzák, K. Smetana Jr., Z. Melkova, H. Kaltner, M. Filipec, F.-T. Liu, H.-J. Gabius
Br. J. Ophthalmol. 85, 1336-1340 (2001).

Detection of Macrophage Migration Inhibitory Factor (MIF) in Human Cholesteatomas and Functional Implications of Correlations to Recurrence Status and to Expression of Matrix Metalloproteinases-3/9, Retinoid Acid Receptor-b and Antiapoptotic Galectin-3.
G. Choufani, R. Ghanooni, C.. Decaestecker, C. Delbrouck, P. Simon, M.-P. Schüring, Y. Zick, S. Hassid, H.-J. Gabius, R. Kiss
Laryngoscope 111, 1656-1662 (2001).

Negative Regulation of Neuroblastoma Cell Growth by Carbohydrate-Dependent Surface Binding of Galectin-1 and Functional Divergence from Galectin-3.
J. Kopitz, C. von Reitzenstein, S. André, H. Kaltner, J. Uhl, V. Ehemann, M. Cantz, H.-J. Gabius
J. Biol. Chem. 276, 35917-35923 (2001).

Probing the Cons and Pros of Lectin-Induced Immunomodulation: Case Studies for the Mistletoe Lectin and Galectin-1.
H.-J. Gabius
Biochimie 83, 659-666 (2001).

Low-Dose Intragastric Administration of Phaseolus vulgaris Agglutinin (PHA) Does not Induce Immunoglobulin E (IGE) Production in Sprague-Dawley Rats.
H. Haas, K.-H. Herzig, S. André, J. Galle, A. Gronow, H.-J. Gabius
Glycoconjugate J. 18, 273-275 (2001).

NMR Investigations of Protein-Carbohydrate Interactions. Insight into the Topology of the Bound Conformation of a Lactose Isomer and b-Galactosyl Xyloses to Mistletoe Lectin and Galectin-1.
J. M. Alonso-Plaza, M. A. Canales, J. L. Roldán, A. García-Herrero, L. Iturrino, J. L. Asensio, F. J. Canada, A. Romero, H.-C. Siebert, S. André, D. Solís, H.-J. Gabius, J. Jiménez-Barbero
Biochim. Biophys. Acta 1568, 225-236 (2001).

Lectin(WGA)-Dependent Superoxide Anion Release by Neutrophils as a Prognostic Factor in Lung Cancer.
A. V. Timoshenko, S. André, K. Kayser, H.-J. Gabius
Anticancer Res. 21, 3453-3456 (2001).